Classification: | High Purity Material |
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Content: | Standard |
Application: | Health |
Product Purity: | >99% |
Delivery: | Door to Door Delivery |
Delivery Time: | 6-7days |
Samples: |
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Customization: |
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Retatrutide Basic information |
Product Name: | Retatrutide |
Synonyms: | LY3437943;Retatrutide;GIPR/GLP-1R;Retatrutide/LY3437943/GIPR/GLP-1R;Retaglutide;Retatrutide acetate;LY3437943Retatrutide |
CAS: | 2381089-83-2 |
MF: | |
MW: | 0 |
EINECS: | 200-001-8 |
Retatrutide Chemical Properties |
storage temp. | -20°C |
form | powder |
color | White lyophilized |
Water Solubility | Soluble in water (5mg/ml). |
Retatrutide Usage And Synthesis |
Description | Retatrutide is a novel triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent otropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively. It is an important tool for obesity research. Retatrutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent secretion through activity at the GIP receptor (GIPR) or the GLP-1R. Retatrutide is a synthetic peptide with glucose-lowering effects. It is an antidiabetic agent against type 2 diabetes (T2D), stimulating and suppressing glucagon secretion in a glucose-dependent manner. Retatrutide was also shown to delay gastric emptying, lower fasting and postprandial glucose concentration, decrease food intake and reduce body weight in patients with type 2 diabetes. |
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