Customization: | Available |
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CAS No.: | 42464-96-0 |
Classification: | High Purity Material |
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NNMTi Basic information |
Product Name: | NNMTi |
Synonyms: | 5-amino-1-methylquinolin-1-ium iodide;5-amino-1MQ;NNMTi;5-Amino-1methylquinolinium iodide;5-Amino-1-methylquinolinium;NNMTi,inhibit,fusion,muSC,muscle stem cell,NNMT,Inhibitor,regenerative;NNMTi 5-amino-1MQ;1-methylquinolin-1-ium-5-amine iodide |
CAS: | 42464-96-0 |
NNMTi Chemical Properties |
Melting point | 213-214 °C |
storage temp. | Store at -20°C |
solubility | Soluble in DMSO |
Description | NNMTi (CAS 42464-96-0) is a nicotinamide N-methyltransferase (NNMT) inhibitor that promotes myoblast differentiation. NNMT is a fundamental cytosolic biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics. NNMTi treatment combined with lean diet substitution accelerated improved body weight fat loss, increased whole-body lean mass to body weight ratio, reduced liver epididymal white adipose tissue weights, decreased liver adiposity, improved hepatic steatosis, relative to a lean diet substitution alone. |
Chemical Properties | Brown solid. |
Uses | NNMTi is an enzyme overexpressed during skeletal muscle aging and is associated with the repair of damage to the NAD+ pathway, dysregulation of sirtuin1 activity, and increased senescence of muscle stem cells. |
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